Writing a scientific manuscript for peer-reviewed publication is a demanding task that requires clear structure, precision, and adherence to specific guidelines. This guide provides essential information and practical tips to help you prepare an original research manuscript efficiently and correctly. The recommendations are based on extensive experience in editing and proofreading scientific texts, enabling you to avoid common mistakes from the outset.
A typical manuscript follows a standard structure: Title, Abstract, Introduction, Materials and Methods, Results, Discussion, and Conclusion. However, writing these sections in this order is often inefficient. Instead, consider the following sequence for a smoother process:
Results
Materials and Methods
Discussion
Introduction
Conclusion
Abstract
Title
This approach facilitates logical flow and clarity. Beyond these core sections, you will also need to address keywords, highlights, acknowledgements, abbreviations, author contributions, funding statements, data availability, ethics statements, and the cover letter.
Choice of Journal
To begin effectively, select your target journal early in the writing process. Download its Author Guidelines and comply with formatting requirements, especially for figures and references. This ensures your manuscript meets the journal’s standards and increases chances of acceptance. Be cautious of predatory journals that promise rapid, low-cost publication but lack scientific rigor. Examples of trusted publishers include but are not limited to Elsevier, Plos, Springer, Frontiers, Nature, BMC, and Karger. Evaluate journals by reviewing recent publications in your research field to identify the best fit. Remember, even well-conducted studies with negative results merit publication, contributing valuable knowledge and potentially reducing redundant experiments.
Referencing
Start your manuscript preparation by conducting a thorough literature search early. Use a reference management program such as Endnote or alternatives to organize sources and streamline citation formatting.
After these Prearrangements, Let’s get Started
Collect all relevant materials — protocols, lab notes, posters, presentations — and select the most critical data to develop a coherent narrative. Collaborate with supervisors or co-authors during this brainstorming phase to refine your story. Separate supplementary or supporting data from the main manuscript to maintain focus and clarity. This preparation prevents writer’s block and lays a solid foundation for your manuscript.
Following these structured steps will facilitate a clear, precise, and professionally prepared scientific manuscript ready for peer review.
Summary
Choose the journal for submission and study its formatting requirements
Select and use a reference management tool to organize your literature
Gather all existing data and materials related to your project to outline your manuscript’s story
